Single or multiple daily doses of aminoglycosides
نویسندگان
چکیده
منابع مشابه
Single or multiple daily doses of aminoglycosides: a meta-analysis.
OBJECTIVE To assess relative efficacy and toxicity of aminoglycosides given by single daily dose compared with multiple daily doses. DESIGN Meta-analysis of 21 randomised trials identified through MEDLARS (1966 to January 1995). Data were overviewed with fixed effects and random effects models and with meta-regression analysis. SUBJECTS Total of 3091 patients with bacterial infection, most ...
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Data extraction Data were extracted on study characteristics, drug regimen, sample size, compliance, mean baseline rating on depression scales, and percentage change at end point. Treatment effects were calculated and weighted in a meta-analysis. 3 different weights were used for each treatment effect to reflect 3 different assumptions about the correlation between baseline and follow up depres...
متن کاملA meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides.
We performed a meta-analysis of the efficacy and toxicity of single daily dosing (SDD) vs. multiple daily dosing of aminoglycosides and summarized the results of the four previously published meta-analyses on this subject. Our analysis showed that the overall clinical response rate favored SDD therapy (mean difference, +3.06%; 95% confidence limit [CL], +0.17% to +5.95%; P = .04). However, we f...
متن کاملMeta-analysis: A single daily dose of aminoglycosides is as effective as multiple daily dosing with less nephrotoxicity
and Commentary also published in ACP Journal Club. 1996; 125:10.
متن کاملMeta-analysis: A single daily dose of aminoglycosides is as effective as multiple daily dosing with less nephrotoxicity
and Commentary also published in ACP Journal Club. 1996; 125:10.
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ژورنال
عنوان ژورنال: BMJ
سال: 1996
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.313.7055.490